🍎 Mind & Apple Archives
GLUCOSAMINA: LA PARADOJA DEL ALZHEIMER
GLUCOSAMINA: LA PARADOJA DEL ALZHEIMER Un aminoazúcar de doble filo: escudo en el cerebro sano, detonante una vez iniciada la…
CASE FILE C8: FORENSIC ANATOMY OF AN ETERNAL POISON
CASE FILE C8: FORENSIC ANATOMY OF AN ETERNAL POISON From the miracle of Teflon to the eternal chemical that already dwells in the…
The Ivermectin Case: Oncological Promise and Clinical Reality
The preclinical promise of ivermectin against cancer and why clinical evidence in humans has not yet confirmed it…
Vitamin D: Anatomy of a Deficiency
VITAMIN D: ANATOMY OF A DEFICIENCY Metabolism, the silent deficiency in Mexico, and evidence-based supplementation Editorial note…
The Coca-Cola File: Bought Science, Stolen Water, and the Hidden Price of a Global Empire
Six documented fronts concerning Coca-Cola: public health, funded science, water, labor litigation, and plastic.
Vaccines: The Forensic Anatomy of the 154 Million Lives They Stole from Death (1796–2024)
FROM SMALLPOX TO 154 MILLION: THE FORENSIC ANATOMY OF VACCINES Two Centuries of Immunization, Statistics and…
HEBERSaVax: the Cuban cancer vaccine that breaks the Bevacizumab paradigm
HEBERSaVax (CIGB-247) is the Cuban therapeutic cancer vaccine that targets VEGF through a dual mechanism. Data as of 6…
The Nestlé Archive: Six Decades Under Scrutiny
Six decades of public records on Nestlé: the Motarjemi ruling, the double standard on sugar in Cerelac, the Buitoni case,…
COVID-19 Vaccines: A Six-Year Forensic Anatomy of Pharmacovigilance, Litigation, and Contractual Opacity (2020–2026)
Six years of clinical evidence, court rulings, and opaque contracts. A technical dossier on AstraZeneca, Janssen, mRNA, the Pfizergate scandal…
The Sildenafil Archive (Vol. I): Hacking Nitric Oxide
Sildenafil citrate: PDE5 enzyme hacking, Pfizer monopoly, STRIDER trial and the NICU paradox.
// VIDEOS
Coming soon. We are preparing the audiovisual content for the archive.
Comprehensive Investigation into the Fungal Hypothesis in Parkinson's Disease: Etiology, Pathogenic Mechanisms, and Methodological Controversies
Cognition Longevity & Metrics
This narrative review integrates immunohistochemical, genomic, epidemiological, and mechanistic evidence that supports and critiques the hypothesis of a fungal infection of the central nervous system as a contributor to Parkinson's disease (PD). The findings of Pisa, Alonso, and Carrasco on the detection of fungal antigens and DNA in post-mortem brain tissue from PD patients are discussed, along with the proposed routes of entry (hematogenous, intestinal, and olfactory), the pathogenic mechanisms (L-DOPA sequestration by Malassezia, mycotoxins, Sup35 cross-seeding, CARD9/NLRP3 neuroinflammation), and the methodological objections (low biomass, kitome, amplification artifacts) raised by Eisenhofer et al. The synthesis proposes a multi-impact model in which fungal infection acts as a cofactor, alongside genetic susceptibility and gut dysbiosis, rather than as a sole cause. Keywords: Parkinson's disease; α-synuclein; brain mycobiome; Malassezia; Sup35; gut-brain-microbiota axis; neuroinflammation; low biomass; kitome.